Cocet

Generic Name: acetaminophen and codeine (a SEET a MIN o fen and KOE deen)

Brand Names: Capital with Codeine Suspension, Cocet, Cocet Plus, EZ III, Tylenol with Codeine #3, Tylenol with Codeine #4, Vopac

What is Cocet (acetaminophen and codeine)?

Codeine is in a group of drugs called narcotic pain relievers. Acetaminophen is a less potent pain reliever that increases the effects of codeine.

The combination of acetaminophen and codeine is used to relieve moderate to severe pain.

Acetaminophen and codeine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Cocet (acetaminophen and codeine)?

Tell your doctor if you have ever had alcoholic liver disease (cirrhosis) or if you drink more than 3 alcoholic beverages per day. You may not be able to take acetaminophen. Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. Codeine may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it. Acetaminophen and codeine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What should I discuss with my healthcare provider before taking Cocet (acetaminophen and codeine)?

Do not use this medication if you are allergic to acetaminophen (Tylenol) or codeine. Codeine may be habit-forming and should be used only by the person it was prescribed for. Never share acetaminophen and codeine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

Tell your doctor if you drink more than three alcoholic beverages per day or if you have ever had alcoholic liver disease (cirrhosis). You may not be able to take medication that contains acetaminophen.

If you have any of these other conditions, you may need a dose adjustment or special tests:

• 
  

  asthma, COPD, sleep apnea, or other breathing disorders;

  
  


• liver or kidney disease;


• 
  

  a history of head injury or brain tumor;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  low blood pressure;

  
  


• 
  

  a stomach or intestinal disorder;

  
  


• 
  

  underactive thyroid;

  
  


• 
  

  Addison's disease or other adrenal gland disorder;

  
  


• 
  

  enlarged prostate, urination problems;

  
  


• 
  

  curvature of the spine;

  
  


• 
  

  mental illness; or

  
  


• 
  

  a history of drug or alcohol addiction.

  
  

FDA pregnancy category C. It is not known whether this medication is harmful to an unborn baby, but it could cause breathing problems or addiction/withdrawal symptoms in a newborn. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Acetaminophen and codeine can pass into breast milk and may harm a nursing baby. The use of codeine by some nursing mothers may lead to life-threatening side effects in the baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Cocet (acetaminophen and codeine)?

Take exactly as prescribed by your doctor. Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

One acetaminophen and codeine tablet may contain up to 650 mg of acetaminophen. Know the amount of acetaminophen in the specific product you are taking.

Take this medicine with food or milk to ease stomach upset.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Drink 6 to 8 full glasses of water daily to help prevent constipation while you are taking acetaminophen and codeine. Do not use a stool softener (laxative) without first asking your doctor. Do not stop using acetaminophen and codeine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using acetaminophen and codeine.

This medication can cause unusual results with certain urine tests. Tell any doctor who treats you that you are using acetaminophen and codeine.

If you need surgery, tell the surgeon ahead of time that you are using acetaminophen and codeine. You may need to stop using the medicine for a short time.

Store at room temperature away from moisture and heat. Keep track of the amount of medicine used from each new bottle. Codeine is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

What happens if I miss a dose?

Since this medication is taken as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen and codeine can be fatal.

Overdose symptoms may include extreme drowsiness, pinpoint pupils, cold and clammy skin, fainting, weak pulse, seizure (convulsions), coma, blue lips, shallow breathing, or no breathing.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

What should I avoid while taking Cocet (acetaminophen and codeine)?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen.

Cocet (acetaminophen and codeine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• 
  

  shallow breathing, slow heartbeat;

  
  


• 
  

  feeling light-headed, fainting;

  
  


• 
  

  confusion, unusual thoughts or behavior;

  
  


• 
  

  seizure (convulsions);

  
  


• 
  

  easy bruising or bleeding; or

  
  


• 
  

  nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

  
  

Less serious side effects include:

• 
  

  feeling dizzy or drowsy;

  
  


• 
  

  mild nausea, vomiting, upset stomach, constipation;

  
  


• 
  

  headache;

  
  


• 
  

  blurred vision; or

  
  


• 
  

  dry mouth.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Cocet (acetaminophen and codeine)?

Before taking acetaminophen and codeine, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, other pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by codeine.

Also tell your doctor if you are using any of the following drugs:

• 
  

  glycopyrrolate (Robinul);

  
  


• 
  

  mepenzolate (Cantil);

  
  


• 
  

  atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop);

  
  


• 
  

  bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare);

  
  


• 
  

  a bronchodilator such as ipratroprium (Atrovent) or tiotropium (Spiriva); or

  
  


• 
  

  irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), or propantheline (Pro-Banthine).

  
  

This list is not complete and other drugs may interact with acetaminophen and codeine. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Cocet resources

• Cocet Side Effects (in more detail)
• Cocet Use in Pregnancy & Breastfeeding
• Cocet Drug Interactions
• Cocet Support Group
• 0 Reviews for Cocet - Add your own review/rating

• Cocet Plus Prescribing Information (FDA)


• Tylenol with Codeine Prescribing Information (FDA)


• Vopac Advanced Consumer (Micromedex) - Includes Dosage Information

Compare Cocet with other medications

• Cough
• Osteoarthritis
• Pain

Where can I get more information?

• Your pharmacist can provide more information about acetaminophen and codeine.

See also: Cocet side effects (in more detail)

Telfast 30mg tablets

1. Name Of The Medicinal Product

Telfast 30 mg film-coated tablets

2. Qualitative And Quantitative Composition

Each tablet contains 30 mg of fexofenadine hydrochloride, which is equivalent to 28 mg of fexofenadine.

For a full list of excipients, see section 6.1.

3. Pharmaceutical Form

Film-coated tablet.

Peach round film-coated tablet debossed with “03” on one side and a scripted “e” on the other side.

4. Clinical Particulars

4.1 Therapeutic Indications

Relief of symptoms associated with seasonal allergic rhinitis.

4.2 Posology And Method Of Administration

Paediatric population

• Children 6 to 11 years of age

The recommended dose of Fexofenadine hydrochloride in children aged 6 to 11 years is 30 mg twice daily.

• Children under 6 years of age

The efficacy of Fexofenadine hydrochloride has not been established in children under 6 years of age.

Special population

The safety and efficacy of Fexofenadine hydrochloride in renally or hepatically impaired children have not been established (see section 4.4). Studies conducted in adults in special risk groups (renally or hepatically impaired patients) indicate that it is not necessary to adjust the dose of Fexofenadine hydrochloride in adults.

4.3 Contraindications

Hypersensitivity to the active substance or to any of the excipients.

4.4 Special Warnings And Precautions For Use

The safety and efficacy of fexofenadine hydrochloride in renally or hepatically impaired children have not been established (see section 4.2). Fexofenadine hydrochloride should be administered with caution in these patients.

Patients with a history of or ongoing cardiovascular disease should be warned that, antihistamines as a drug class, have been associated with the adverse events, tachycardia and palpitations (see section 4.8).

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

Interaction studies have only been performed in adults.

Fexofenadine does not undergo hepatic biotransformation and therefore will not interact with other medicinal products through hepatic mechanisms.

Co administration of Fexofenadine hydrochloride with erythromycin or ketoconazole has been found to result in a 2-3 times increase in the level of Fexofenadine in plasma. The changes were not accompanied by any effects on the QT interval and were not associated with any increase in adverse reactions compared to the medicinal products given singly.

Animal studies have shown that the increase in plasma levels of Fexofenadine observed after co administration of erythromycin or ketoconazole, appears to be due to an increase in gastrointestinal absorption and either a decrease in biliary excretion or gastrointestinal secretion, respectively.

No interaction between Fexofenadine hydrochloride and omeprazole was observed. However, the administration of an antacid containing aluminium and magnesium hydroxide gels 15 minutes prior to Fexofenadine hydrochloride caused a reduction in bioavailability, most likely due to binding in the gastrointestinal tract. It is advisable to leave 2 hours between administration of Fexofenadine hydrochloride and aluminium and magnesium hydroxide containing antacids.

4.6 Pregnancy And Lactation

Pregnancy

There are no adequate data from the use of Fexofenadine hydrochloride in pregnant women. Limited animal studies do not indicate direct or indirect harmful effects with respect to effects on pregnancy, embryonal/foetal development, parturition or postnatal development (see section 5.3). Fexofenadine hydrochloride should not be used during pregnancy unless clearly necessary.

Breastfeeding

There are no data on the content of human milk after administering Fexofenadine hydrochloride. However, when terfenadine was administered to nursing mothers Fexofenadine was found to cross into human breast milk. Therefore Fexofenadine hydrochloride is not recommended for mothers breast-feeding their babies.

4.7 Effects On Ability To Drive And Use Machines

On the basis of the pharmacodynamic profile and reported adverse reactions it is unlikely that Fexofenadine hydrochloride tablets will produce an effect on the ability to drive or use machines.

In objective tests, Telfast has been shown to have no significant effects on central nervous system function. This means that patients may drive or perform tasks that require concentration. However, in order to identify sensitive people who have an unusual reaction to medicinal products, it is advisable to check the individual response before driving or performing complicated tasks.

4.8 Undesirable Effects

In controlled clinical trials in children aged 6 to 11 years, the most commonly reported adverse reaction considered at least possibly related to fexofenadine hydrochloride by the investigator was headache. The incidence of headache in pooled data from clinical trials was 1.0% for patients taking fexofenadine hydrochloride 30 mg (673 children) and for patients taking placebo (700 children). There are no clinical safety data in children treated with fexofenadine hydrochloride for periods longer than two weeks

In controlled clinical trials in 845 children aged 6 months to 5 years with allergic rhinitis, 415 children were administered 15 mg or 30 mg of fexofenadine hydrochloride (capsule content sprinkled onto dosing vehicle) and 430 children were administered placebo. There were no unexpected adverse events in the children treated with fexofenadine and the adverse event profile was similar to that of older children and adults (see section 4.2).

In adults, the following undesirable effects have been reported in clinical trials, with an incidence similar to that observed with placebo:

Nervous system disorders

Common (

Gastrointestinal disorders

Common (

General disorders and administration site conditions

Uncommon (

In adults, the following undesirable effects have been rarely (

Immune system disorders

hypersensitivity reactions with manifestations such as angioedema, chest tightness, dyspnoea, flushing and systemic anaphylaxis

Psychiatric disorders

insomnia, nervousness, sleep disorders or paroniria, such as nightmares

Cardiac disorders

tachycardia, palpitations

Gastrointestinal disorders

diarrhoea

Skin and subcutaneous tissue disorders

rash, urticaria, pruritus

4.9 Overdose

Dizziness, drowsiness, fatigue and dry mouth have been reported with overdose of Fexofenadine hydrochloride. Doses up to 60 mg twice daily for two weeks have been administered to children, and single doses up to 800 mg and doses up to 690 mg twice daily for 1 month or 240 mg once daily for 1 year have been administered to healthy adult subjects without the development of clinically significant adverse reactions as compared with placebo. The maximum tolerated dose of Fexofenadine hydrochloride has not been established.

Standard measures should be considered to remove any unabsorbed medicinal product. Symptomatic and supportive treatment is recommended. Haemodialysis does not effectively remove Fexofenadine hydrochloride from blood.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Pharmacotherapeutic group: Antihistamines for systemic use, ATC code: R06A X26

Fexofenadine hydrochloride is a non-sedating H₁ antihistamine. Fexofenadine is a pharmacologically active metabolite of terfenadine.

In children aged 6 to 11 years, the suppressive effects of Fexofenadine hydrochloride on histamine – induced wheal and flare were comparable to that in adults at similar exposure. Inhibition of histamine-induced wheal and flare was observed at one hour post dose following single doses of 30 and 60 mg Fexofenadine hydrochloride. Peak inhibitory effects of Fexofenadine generally occurred at 3-6 hours post dose.

In a pooled analysis of three placebo-controlled double-blind phase III studies, involving 1369 children with seasonal allergic rhinitis aged 6 to 11 years, Fexofenadine hydrochloride at 30 mg twice daily was significantly better than placebo in reducing total symptom score (p=0.0001). All individual component symptoms including rhinorrhea (p=0.0058), sneezing (p=0.0001), itchy/ watery/red eyes (p=0.0001), itchy nose/ palate and throat (p=0.0001), and nasal congestion (p=0.0334) were significantly improved by fexofenadine hydrochloride.

In children aged 6 to 11 years, no significant differences in QT_c were observed following up to 60 mg Fexofenadine hydrochloride twice daily for two weeks compared with placebo. No significant differences in QT_c intervals were observed in adult and adolescent patients with seasonal allergic rhinitis, when given Fexofenadine hydrochloride up to 240 mg twice daily for 2 weeks when compared with placebo. Also, no significant change in QT_c intervals was observed in healthy adult subjects given Fexofenadine hydrochloride up to 60 mg twice daily for 6 months, 400 mg twice daily for 6.5 days and 240 mg once daily for 1 year, when compared with placebo. Fexofenadine at concentrations 32 times greater than the therapeutic concentration in man had no effect on the delayed rectifier K+ channel cloned from human heart.

5.2 Pharmacokinetic Properties

Fexofenadine hydrochloride is rapidly absorbed into the body following oral administration, with T_max occurring at approximately 1-3 hours post dose. In children, the mean C_max value was approximately 128 ng/ml following a single dose oral administration of 30 mg Fexofenadine hydrochloride.

A dose of 30 mg BID was determined to provide plasma levels (AUC) in paediatric patients which are comparable to those achieved in adults with the approved adult regimen of 120 mg once daily.

After oral administration in adults, Fexofenadine is 60-70% plasma protein bound. Fexofenadine undergoes negligible metabolism (hepatic or non-hepatic), as it was the only major compound identified in urine and faeces of animals and man. The plasma concentration profiles of Fexofenadine follow a bi-exponential decline with a terminal elimination half-life ranging from 11 to 15 hours after multiple dosing. The single and multiple dose pharmacokinetics of Fexofenadine are linear for oral doses up to 120 mg BID. A dose of 240 mg BID produced slightly greater than proportional increase (8.8%) in steady state area under the curve, indicating that Fexofenadine pharmacokinetics are practically linear at these doses between 40 mg and 240 mg taken daily. The major route of elimination is believed to be via biliary excretion while up to 10% of ingested dose is excreted unchanged through the urine.

5.3 Preclinical Safety Data

Dogs tolerated 450 mg/kg administered twice daily for 6 months and showed no toxicity other than occasional emesis. Also, in single dose dog and rodent studies, no treatment-related gross findings were observed following necropsy.

Radiolabelled Fexofenadine hydrochloride in tissue distribution studies of the rat indicated that Fexofenadine did not cross the blood brain barrier.

Fexofenadine hydrochloride was found to be non-mutagenic in various in vitro and in vivo mutagenicity tests.

The carcinogenic potential of Fexofenadine hydrochloride was assessed using terfenadine studies with supporting pharmacokinetic studies showing Fexofenadine hydrochloride exposure (via plasma AUC values). No evidence of carcinogenicity was observed in rats and mice given terfenadine (up to 150 mg/kg/day).

In a reproductive toxicity study in mice, Fexofenadine hydrochloride did not impair fertility, was not teratogenic and did not impair pre- or postnatal development.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Tablet core :

Microcrystalline Cellulose

Pregelatinised Starch

Croscarmellose Sodium

Magnesium Stearate

Film coat:

Hypromellose

Povidone

Titanium Dioxide (E171)

Colloidal Anhydrous Silica

Macrogol

Pink Iron oxide (E172) blend

Yellow Iron oxide (E172) blend

6.2 Incompatibilities

Not applicable.

6.3 Shelf Life

3 years

6.4 Special Precautions For Storage

This medicinal product does not require any special storage condition

6.5 Nature And Contents Of Container

PVC/PE/PVDC/Al blisters, packaged into cardboard boxes. 1, 2, 4, 8, 10 or 15 (sample only); 20, 30, 40, 50, 60 and 100 tablets per package.

Not all pack sizes may be marketed.

6.6 Special Precautions For Disposal And Other Handling

No special requirements

7. Marketing Authorisation Holder

Aventis Pharma Ltd

50 Kings Hill

West Malling

Kent

ME19 4AH

Or trading as

Sanofi-aventis

One Onslow Street

Guildford

Surrey

GU1 4YS

8. Marketing Authorisation Number(S)

PL 04425/0162

9. Date Of First Authorisation/Renewal Of The Authorisation

1^st April 2003

10. Date Of Revision Of The Text

22 November 2011

Lansodine

Lansodine may be available in the countries listed below.

Ingredient matches for Lansodine

Povidone Iodine

Povidone-Iodine is reported as an ingredient of Lansodine in the following countries:

• Myanmar

International Drug Name Search

Lapibal

Lapibal may be available in the countries listed below.

Ingredient matches for Lapibal

Mecobalamin

Mecobalamin is reported as an ingredient of Lapibal in the following countries:

• Indonesia

International Drug Name Search

Aspercreme

In the US, Aspercreme (trolamine salicylate topical) is a member of the drug class miscellaneous topical agents and is used to treat Back Pain, Bursitis, Osteoarthritis, Pain, Period Pain, Raynaud's Syndrome, Rheumatoid Arthritis and Tendonitis.

US matches:

• Aspercreme Cream

Ingredient matches for Aspercreme

Trolamine

Trolamine salicylate (a derivative of Trolamine) is reported as an ingredient of Aspercreme in the following countries:

• United States

International Drug Name Search

Neoral

Generic Name: cyclosporine (SYE kloe SPOR een)

Brand Names: Gengraf, Neoral, SandIMMUNE

What is Neoral (cyclosporine)?

Cyclosporine lowers your body's immune system. The immune system helps your body fight infections. The immune system can also fight or "reject" a transplanted organ such as a liver or kidney. This is because the immune system treats the new organ as an invader.

Cyclosporine is used to prevent organ rejection after a kidney, liver, or heart transplant.

Cyclosporine is also used to treat severe psoriasis or severe rheumatoid arthritis.

Cyclosporine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Neoral (cyclosporine)?

You may not be able to use this medication if you have kidney disease, untreated or uncontrolled hypertension (high blood pressure), or any type of cancer.

If you are being treated for psoriasis, you should not receive light therapy (PUVA or UVB) or radiation treatments while you are receiving cyclosporine. Make sure all doctors involved in your care know you are taking cyclosporine.

You may take cyclosporine with or without food, but take it the same way each time. Cyclosporine should be given in two separate doses each day. Try to take the medication at the same dosing times each day.

If there are any changes in the brand or form of cyclosporine you use, your dosage needs may change. Always check your refills to make sure you have received the correct brand and type of medicine prescribed by your doctor. Call your doctor at once if you have any signs of kidney failure, such as urinating less than usual or not at all, drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting, swelling, weight gain, or feeling short of breath. Do not receive a "live" vaccine while you are being treated with cyclosporine. The live vaccine may not work as well during this time, and may not fully protect you from disease. There are many other medicines that can cause serious medical problems if you take them together with cyclosporine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

What should I discuss with my health care provider before taking Neoral (cyclosporine)?

You should not use this medication if you are allergic to cyclosporine. You may not be able to use cyclosporine if you have:

• 
  

  kidney disease;

  
  


• 
  

  untreated or uncontrolled high blood pressure; or

  
  


• 
  

  any type of cancer.

  
  

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take cyclosporine:

• 
  

  psoriasis that has been treated with PUVA, UVB, radiation, methotrexate (Trexall), or coal tar; or

  
  


• 
  

  if you are also taking an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), etodolac (Lodine), indomethacin (Indocin), and others.

  
  

FDA pregnancy category C. It is not known whether cyclosporine is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Cyclosporine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Neoral (cyclosporine)?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

You may take cyclosporine with or without food, but take it the same way each time. Cyclosporine should be given in two separate doses each day. Try to take the medication at the same dosing times each day.

If there are any changes in the brand or form of cyclosporine you use, your dosage needs may change. Always check your refills to make sure you have received the correct brand and type of medicine prescribed by your doctor.

Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Sandimmune oral solution may be mixed with milk, chocolate milk, or orange juice at room temperature to make the medicine taste better. Neoral "modified" (microemulsion) oral solution should be mixed with orange juice or apple juice that is at room temperature.

Cyclosporine can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Your blood pressure and kidney function may also need to be checked. Do not miss any scheduled appointments.

Your condition may need to be treated with a combination of different drugs. For best treatment results, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor. Every person taking cyclosporine should remain under the care of a doctor.

Store cyclosporine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose can cause nausea, vomiting, pain in your upper stomach, loss of appetite, jaundice (yellowing of the skin or eyes), and urinating less than usual or not at all.

What should I avoid while taking Neoral (cyclosporine)?

Avoid exposure to sunlight, sunlamps, or tanning beds. Cyclosporine can make your skin more sensitive to sunlight, and a sunburn may result. Wear protective clothing and use sunscreen (SPF 15 or higher) when you are outdoors.

If you are being treated for psoriasis, you should not receive light therapy (PUVA or UVB) or radiation treatments while you are receiving cyclosporine. Make sure all doctors involved in your care know you are taking cyclosporine.

Do not receive a "live" vaccine while you are being treated with cyclosporine. The live vaccine may not work as well during this time, and may not fully protect you from disease.

Avoid eating grapefruit or drinking grapefruit juice. Grapefruit may interact with cyclosporine and increase your blood levels of this medication.

Neoral (cyclosporine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• 
  

  urinating less than usual or not at all;

  
  


• 
  

  drowsiness, confusion, mood changes, increased thirst;

  
  


• 
  

  swelling, weight gain, feeling short of breath;

  
  


• 
  

  blurred vision, headache or pain behind your eyes, sometimes with vomiting;

  
  


• 
  

  seizure (convulsions);

  
  


• 
  

  muscle pain or weakness, fast heart rate, feeling light-headed;

  
  


• 
  

  signs of infection such as fever, chills, sore throat, flu symptoms;

  
  


• 
  

  pale skin, easy bruising or bleeding, unusual weakness; or

  
  


• 
  

  nausea, stomach pain, loss of appetite, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

  
  

Less serious side effects may include:

• 
  

  tremors or shaking;

  
  


• 
  

  increased hair growth;

  
  


• 
  

  headache or body pain;

  
  


• 
  

  diarrhea, constipation, vomiting; or

  
  


• 
  

  numbness or tingly feeling.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Neoral (cyclosporine)?

Many drugs can interact with cyclosporine. Below is just a partial list. Tell your doctor about all other medications you are using, especially:

• 
  

  etoposide (VePesid, Etopophos);

  
  


• 
  

  lithium (Eskalith, Lithobid);

  
  


• 
  

  methotrexate (Rheumatrex, Trexall);

  
  


• 
  

  nefazodone;

  
  


• 
  

  repaglinide (Prandin);

  
  


• 
  

  St. John's wort;

  
  


• 
  

  an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik);

  
  


• 
  

  a heart or blood pressure medication such as candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro, Avalide), losartan (Cozaar, Hyzaar), valsartan (Diovan), telmisartan (Micardis), or olmesartan (Benicar);

  
  


• 
  

  medicines used to treat ulcerative colitis, such as mesalamine (Pentasa) or sulfasalazine (Azulfidine);

  
  


• 
  

  other medicines used to prevent organ transplant rejection, such as sirolimus (Rapamune) or tacrolimus (Prograf);

  
  


• 
  

  pain or arthritis medicines such as aspirin (Anacin, Excedrin), acetaminophen (Tylenol), diclofenac (Voltaren), etodolac (Lodine), ibuprofen (Advil, Motrin), indomethacin (Indocin), naproxen (Aleve, Naprosyn), and others;

  
  


• 
  

  IV antibiotics such as amphotericin B (Fungizone, AmBisome, Amphotec, Abelcet), amikacin (Amikin), bacitracin (Baci-IM), capreomycin (Capastat), gentamicin (Garamycin), kanamycin (Kantrex), streptomycin, or vancomycin (Vancocin, Vancoled);

  
  


• 
  

  antiviral medicines such as adefovir (Hepsera), cidofovir (Vistide), or foscarnet (Foscavir); or

  
  


• 
  

  cancer medicine such as aldesleukin (Proleukin), carmustine (BiCNU, Gliadel), cisplatin (Platinol), ifosfamide (Ifex), oxaliplatin (Eloxatin), streptozocin (Zanosar), or tretinoin (Vesanoid).

  
  

This list is not complete and there are many other medicines that can cause serious medical problems if you take them together with cyclosporine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

More Neoral resources

• Neoral Side Effects (in more detail)
• Neoral Use in Pregnancy & Breastfeeding
• Drug Images
• Neoral Drug Interactions
• Neoral Support Group
• 1 Review for Neoral - Add your own review/rating

• Neoral Advanced Consumer (Micromedex) - Includes Dosage Information


• Neoral Prescribing Information (FDA)


• Neoral MedFacts Consumer Leaflet (Wolters Kluwer)


• Cyclosporine Prescribing Information (FDA)


• Cyclosporine Monograph (AHFS DI)


• Cyclosporine MedFacts Consumer Leaflet (Wolters Kluwer)


• Gengraf Prescribing Information (FDA)


• Sandimmune Prescribing Information (FDA)


• cyclosporine Ophthalmic Advanced Consumer (Micromedex) - Includes Dosage Information

Compare Neoral with other medications

• Crohn's Disease
• Idiopathic Thrombocytopenic Purpura
• Inflammatory Bowel Disease
• Organ Transplant, Rejection Prophylaxis
• Organ Transplant, Rejection Reversal
• Psoriasis
• Rheumatoid Arthritis
• Ulcerative Colitis

Where can I get more information?

• Your pharmacist can provide more information about cyclosporine.

See also: Neoral side effects (in more detail)

Beplarid

Beplarid may be available in the countries listed below.

Ingredient matches for Beplarid

Beraprost

Beraprost sodium (a derivative of Beraprost) is reported as an ingredient of Beplarid in the following countries:

• Japan

International Drug Name Search